Séminaire du Dr. Brigitte Pertschy (University of Graz, Austria), BEM, Amphi 1021004.
Title: “Functions of snoRNPs beyond pseudouridylation and methylation”
Brigitte Pertschy studies the mechanisms of eukaryotic ribosome biogenesis, applying genetic, biochemical and cell biological approaches, mainly using yeast as model system. Her work has illuminated the protective role of specialized chaperones in safeguarding newly synthesized ribosomal proteins on their assembly path, opening up a new research direction in the ribosome biogenesis field. Moreover, she has unveiled the pivotal role of small RNAs as facilitators of RNA folding in ribosome biogenesis. In addition, Brigitte Pertschy´s group aims to unravel the mechanisms through which the ribosome biogenesis pathway influences aging, and to investigate its interplay with other key proteostasis processes like autophagy. Furthermore, she seeks to explore the potential of inhibiting ribosome biogenesis as a novel strategy for anti-aging intervention.